The following is a quote from Culinology "The Official Magazine of the Research Chefs Association" Decenber 2007, page 11. "Chef Heston Blumenthal was curious to know which parts of the brain are affected by spicy foods. So, the owner of The Fat Duck, Bray, England, sent his head chef, Ashley Palmer-Watts, into an MRI scanner and intravenously fed him chile oil - twice the dose, in fact, that doctors had deemed safe. Palmer-Watts survived the double shot, and Blumenthal watched and learned the point at which the pain of ingesting chile is overcome by pleasurable endorphins." Would an intravenous injection of chile oil even be detectable? If the needle cannula put the chile oil below the area where the trigeminal receptors were, there could not be any sensation, could there? The receptors are not everywhere on the body, are they? I suppose some of the oil would "bloom" up to the underside of the receptors and trigger them. It might also travel through the bloodstream and engage the under side of the sensitive nerves. If it works, mainlining chile oil is an extreme way to be a chile-head. "Open Fields" sound like a better way. It may even have been a better way to answer Chef Blumenthal's question!